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マルチスケール量子― 古典生命インターフェース研究コンソーシアム

論文

  1. Light-harvesting by antenna-containing xanthorhodopsin from an antarctic cyanobacterium

    María del Carmen Marín*, Shunya Murakoshi, Andrey Rozenberg, Tatsuki Tanaka, Masae Konno, Wataru Shihoya*, Osamu Nureki*, Keiichi Inoue*, Oded Béjà* . Communications Biology, ,

    doi: 10.1038/s42003-025-09294-z

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  2. Protonation-enhanced energy transfer in xanthorhodopsin Kin4B8

    Kazuhiro J. Fujimoto*, Yuta A. Tsuzuki, Masae Konno, Takashi Nagata, Rintaro Murakami, Keiichi Inoue*, Takeshi Yanai* . The Journal of Physical Chemistry Letters, 16, 11884-11892

    doi: 10.1021/acs.jpclett.5c02898

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  3. Light-induced FTIR spectroscopy of visual rhodopsin microcrystals grown in lipidic cubic phase

    Yosuke Mizuno†, Valérie Panneels†, Yuji Furutani*, Gebhard F.X. Schertler, Hideki Kandori, Kota Katayama* . Journal of Molecular Biology, 437, 169487

    doi: 10.1016/j.jmb.2025.169487

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  4. Hydrated ionic liquids enhance stability and preserve functionality in transmembrane proteins

    Kyoko Fujita*, Kaho Ishii, Kazune Kobayashi, Yuji Furutani*, Yutaka Takebe, Eiichi Mizohata* . International Journal of Biological Macromolecules, 330, 148096

    doi: 10.1016/j.ijbiomac.2025.148096

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  5. Apusomonad rhodopsins: A new family of ultraviolet to blue light–absorbing rhodopsin channels

    Luis Javier Galindo*, Shunki Takaramoto, Takashi Nagata, Andrey Rozenberg, Hiroto Takahashi, Oded Béjà, Keiichi Inoue* . Proceedings of the National Academy of Sciences of the United States of America, 122, e2510619122

    doi: 10.1073/pnas.2510619122

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  6. Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota

    Takayoshi Fujiwara, Toshiaki Hosaka, Masumi Hasegawa-Takano, Yosuke Nishimura, Kento Tominaga, Kaho Mori, Satoshi Nishino, Yuno Takahashi, Tomomi Uchikubo-Kamo, Kazuharu Hanada, Takashi Maoka, Shinichi Takaichi, Keiichi Inoue*, Mikako Shirouzu*, Susumu Yoshizawa* . Nature Microbiology, 10, 2603-2615

    doi: 10.1038/s41564-025-02109-1

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  7. HulaChrimson: A Chrimson-like cation channelrhodopsin discovered using freshwater metatranscriptomics from Lake Hula

    Hiroto Takahashi, Shunki Takaramoto, Takashi Nagata, Shai Fainsod, Yoshitaka Kato, Oded Béjà, Keiichi Inoue . Biophysics and Physicobiology, 22, e220014

    doi: 10.2142/biophysico.bppb-v22.0014

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  8. Significant effects of excitonic coupling and charge transfer on the circular dichroism spectrum of photosynthetic light-harvesting I complex

    Rio Tsuji, Kazuhiro J. Fujimoto*, Naho Hiwatashi, Zheng-Yu Wang-Otomo, Takeshi Yanai* . The Journal of Physical Chemistry B, 129, 6153–6162 (2025)

    doi: 10.1021/acs.jpcb.5c02145

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  9. In-insect synthesis of oxygen-doped molecular nanocarbons

    Atsushi Usami*, Hideya Kono, Vic Austen, Quan Manh Phung, Hiroki Shudo, Tomoki Kato, Hayato Yamada, Akiko Yagi, Kazuma Amaike, Kazuhiro J. Fujimoto*, Takeshi Yanai*, Kenichiro Itami* . Science, 388, 1055-1061 (2025)

    doi: 10.1126/science.adp9384

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  10. A constructive study based on Gloeobacter rhodopsin to explore the origin of extreme redshift and nontypical isomerization of bestrhodopsin

    Takashi Nagata, Yuma Kawasaki, Masae Konno, Keiichi Inoue* . The Journal of Physical Chemistry Letters, 16, 6622-6626

    doi: 10.1021/acs.jpclett.5c00869

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  11. Structural changes in the retinal chromophore and ion-conducting pathway of an anion channelrhodopsin GtACR1

    Keisei Shibata*, Yuma Kawasaki, Shunki Takaramoto, Masaya Watanabe, Masahiro Fukuda, Ryohei Ono, Hideaki E. Kato, Hidefumi Akiyama, Keiichi Inoue* . The Journal of Physical Chemistry Letters, 16, 6234-6241

    doi: 10.1021/acs.jpclett.5c01008

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  12. The role of retinal chromophore photoisomerization in enhanced inward proton-pumping activity of xenorhodopsin from Nanosalina

    Yuma Ito, Tatsuro Nishikino, Hideki Kandori, Yuji Furutani . Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1866, 149556 (2025)

    doi: 10.1016/j.bbabio.2025.149556

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  13. Light-harvesting by antenna-containing rhodopsins in pelagic Asgard archaea

    Gali Tzlil, María del Carmen Marín, Yuma Matsuzaki, Probal Nag†, Shota Itakura, Yosuke Mizuno, Shunya Murakoshi, Tatsuki Tanaka, Shirley Larom, Masae Konno, Rei Abe-Yoshizumi, Ana Molina-Márquez, Daniela Bárcenas-Pérez, José Cheel, Michal Koblížek, Rosa León, Kota Katayama, Hideki Kandori, Igor Schapiro, Wataru Shihoya*, Osamu Nureki*, Keiichi Inoue*, Andrey Rozenberg*, Ariel Chazan*, Oded Béjà* . Nature Microbiology, 10, 1484-1500 (2025)

    doi: 10.1038/s41564-025-02016-5

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  14. Archaerhodopsin 3 is an ideal template for the engineering of highly fluorescent optogenetic reporters

    Krystyna Herasymenko, Danushka Walisinghe, Masae Konno, Leonardo Barneschi, Isabelle de Waele, Michel Sliwa, Keiichi Inoue*, Massimo Olivucci*, Stefan Haacke* . Chemical Science, 16, 761-774 (2025)

    doi: 10.1039/D4SC05120C

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  15. Weak organic acid effect of bacterial light-driven proton-pumping rhodopsin

    Zikun Lyu, Shunki Takaramoto, Keiichi Inoue* . The Journal of Physical Chemistry B, 129, 3198-3206 (2025)

    doi: 10.1021/acs.jpcb.4c06891

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  16. HulaCCR1, a Pump-like Cation Channelrhodopsin Discovered in a Lake Microbiome

    Shunki Takaramoto, Shai Fainsod, Takashi Nagata, Andrey Rozenberg, Oded Béjà, Keiichi Inoue* . Journal of Molecular Biology, 436, 168844 (2024)

    doi: 10.1016/j.jmb.2024.168844

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  17. Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils

    Maho Yagi-Utsumi, Yui Kanaoka, Shogo Miyajima, Satoru G. Itoh, Katsuhiko Yanagisawa, Hisashi Okumura, Takayuki Uchihashi*, Koichi Kato* . Journal of the American Chemical Society, 146, 31518–31528

    doi: 10.1021/jacs.4c08841

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  18. Quantitative Analysis of Therapeutic Antibody Interactions with Fcγ Receptors Using High-Speed Atomic Force Microscopy

    Saeko Yanaka, Hiroki watanabe, Rina Yogo, Mesayamas Kongsema, Sachiko Kondo, Hirokazu Yagi, Takayuki Uchihashi, and Koichi Kato . Biological and Pharmaceutical Bulletin, 4, 1334-338

    doi: 10.1248/bpb.b23-00751

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  19. Prominent Role of Charge Transfer in the Spectral Tuning of Photosynthetic Light-Harvesting I Complex

    Kazuhiro J. Fujimoto*, Rio Tsuji, Zheng-Yu Wang-Otomo, Takeshi Yanai* . ACS Physical Chemistry Au, 4, 499-509

    doi: 10.1021/acsphyschemau.4c00022

    • ITbM

  20. Glu1022.53-mediated early conformational changes in the process of light-induced green cone pigment activation

    Takuma Sasaki, Kota Katayama*, Hiroo Imai, Hideki Kandori* . Biochemistry, 63, 843-854

    doi: 10.1021/acs.biochem.3c00594

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  21. Photoisomerization pathway of the microbial rhodopsin chromophore in solution

    Masahiro Sugiura, Hideki Kandori* . Photochemical & Photobiological Sciences, 23, 1435-1443

    doi: 10.1007/s43630-024-00602-w

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  22. Unique hydrogen-bonding network in a viral channelrhodopsin rhodopsin

    Mako Aoyama, Kota Katayama, Hideki Kandori* . Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1865, 149148

    doi: 10.1016/j.bbabio.2024.149148

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  23. FTIR study of light-induced proton transfer and Ca2+ binding in T82D mutant of TAT rhodopsin

    Teppei Sugimoto, Kota Katayama, Hideki Kandori* . Biophysical Journal, 123, published on the web

    doi: 10.1016/j.bpj.2024.08.005

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  24. SNap bond, a crucial hydrogen bond between Ser in helix 3 and Asn in helix 4, regulates the structural dynamics of heliorhodopsin

    Toshiki Nakamura, Manish Singh, Masahiro Sugiura, Soichiro Kato, Ryo Yamamoto, Hideki Kandori, Yuji Furutani* . Journal of Molecular Biology, 436, 168666

    doi: 10.1016/j.jmb.2024.168666

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  25. Low-temperature FTIR spectroscopy of the L/Q switch of proteorhodopsin

    Tatsuro Nishikino, Teppei Sugimoto, Hideki Kandori* . Physical Chemistry Chemical Physics, 26, 22959-22967

    doi: 10.1039/d4cp02248c

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  26. Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins

    Saeko Yanaka, Rina Yogo, Hirokazu Yagi, Masayoshi Onitsuka, Natsumi Wakaizumi, Yuki Yamaguchi, Susumu Uchiyama, and Koichi Kato . Frontiers in Immunology, 14, 1090898

    doi: 10.3389/fimmu.2023.1090898

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  27. Light-driven Anion-Pumping Rhodopsin with Unique Cytoplasmic Anion-release Mechanism

    Tomohiro Ishizuka, Kano Suzuki, Masae Konno, Keisei Shibata, Yuma Kawasaki, Hidefumi Akiyama, Takeshi Murata*, Keiichi Inoue* . Journal of Biological Chemistry, , in press

    doi: 10.1016/j.jbc.2024.107797

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  28. The high-light-sensitivity Mechanism and Optogenetic Properties of the Bacteriorhodopsin-like Channelrhodopsin GtCCR4

    Tatsuki Tanaka†, Shoko Hososhima†, Yo Yamashita, Teppei Sugimoto, Toshiki Nakamura, Shunta Shigemura, Wataru Iida, Fumiya K. Sano, Kazumasa Oda, Takayuki Uchihashi, Kota Katayama, Yuji Furutani, Satoshi P. Tsunoda, Wataru Shihoya,* Hideki Kandori*, Osamu Nureki* . Molecular Cell, 84, 3530-3544.e6

    doi: 10.1016/j.molcel.2024.08.016

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    • ExCELLS

  29. Magnetic Damping of NiFe Thin Films Grown on Two-Dimensional Chiral Hybrid Lead-iodide Perovskites

    Tempei Hatajiri, Shoya Sakamoto*, Hidetoshi Kosaki, Zikang Tian, Miuko Tanaka, Toshiya Ideue, Keiichi Inoue, Daigo Miyajima, Shinji Miwa* . Physical Review B, 10, 054435

    doi: 10.1103/PhysRevB.110.054435

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  30. Hydrogen-Bonding and Hydrophobic Interaction Networks as Structural Determinants of Microbial Rhodopsin Function

    Éva Bertalan†, Masae Konno†, María del Carmen Marín, Reza Bagherzadeh, Takashi Nagata, Leonid Brown, Keiichi Inoue*, Ana-Nicoleta Bondar* . The Journal of Physical Chemistry B, 128, 7407–7426

    doi: https://doi.org/10.1021/acs.jpcb.4c02946

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  31. Molecular Mechanisms behind Circular Dichroism Spectral Variations between Channelrhodopsin and Heliorhodopsin Dimers

    Kazuhiro J. Fujimoto*, Yuta A. Tsuzuki, Keiichi Inoue, Takeshi Yanai* . The Journal of Physical Chemistry Letters, 15, 2389-2397 (2024)

    doi: 10.1021/acs.jpclett.4c00879

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  32. Extended Theoretical Modeling of Reverse Intersystem Crossing for Thermally Activated Delayed Fluorescence Materials

    Masaya Hagai*, Naoto Inai, Takuma Yasuda*, Kazuhiro J. Fujimoto*, Takeshi Yanai* . Science Advances, 10, eadk3219 (2024)

    doi: 10.1126/sciadv.adk3219

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  33. Spectral Tuning and Excitation-Energy Transfer by Unique Carotenoids in Diatom Light-Harvesting Antenna

    Kazuhiro J. Fujimoto*, Takuya Seki, Takumi Minoda, Takeshi Yanai* . Journal of the American Chemical Society, 146, 3984-3991 (2024)

    doi: 10.1021/jacs.3c12045

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